Role of insulin in type 2 diabetes.

Insulin is the natural treatment of diabetes mellitus. It is the oldest, most potent, and natural treatment option, with unfortunately the highest risk perception. Insulin's role in type 1, GDM and secondary diabetes is like a simple hormone deficiency, viz replacement agent. However, the optimal timing and indication of use of insulin in type 2 diabetes is a matter of considerable debate. Current evidence based thinking allows some practice guidelines in the optimal timing of insulin therapy.