与广州管圆线虫病相关的人类嗜酸性粒细胞性脑膜炎中的脑脊液细胞因子反应

Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis.

作者信息

Intapan Pewpan M, Kittimongkolma Suvicha, Niwattayakul Kanigar, Sawanyawisuth Kittisak, Maleewong Wanchai

机构信息

Department of Parasitology, Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

J Neurol Sci. 2008 Apr 15;267(1-2):17-21. doi: 10.1016/j.jns.2007.09.023. Epub 2007 Oct 24.

DOI:10.1016/j.jns.2007.09.023

PMID:17928005

Abstract

The levels of interleukin 5 (IL5), IL10, and IL13 in the cerebrospinal fluid (CSF) were markedly higher in 30 patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) than in the controls (P<0.001). IL2, IL4, interferon gamma (IFNgamma), and tumor necrosis factor alpha (TNFalpha) levels were not significantly different (P>0.05). IL5, IL10, and TNFalpha levels correlated with eosinophil levels (P=0.023, P=0.018, and P=0.005, respectively) while IL2, IL4, IL13, and IFNgamma did not (P>0.05). Our data suggest that local T-helper-2 (TH2) cytokine responses are predominant in the CSF of patients with EOMA. Data on T lymphocyte-parasite interactions are important for the design of effective vaccines and immunotherapies. The measurement of T-helper-1 (TH1)/TH2 cytokines in the CSF may also have some potential for the diagnosis of parasite associated meningitis.

摘要

30例与广州管圆线虫病相关的嗜酸性粒细胞性脑膜炎（EOMA）患者脑脊液（CSF）中白细胞介素5（IL5）、IL10和IL13水平显著高于对照组（P<0.001）。IL2、IL4、干扰素γ（IFNγ）和肿瘤坏死因子α（TNFα）水平无显著差异（P>0.05）。IL5、IL10和TNFα水平与嗜酸性粒细胞水平相关（分别为P=0.023、P=0.018和P=0.005），而IL2、IL4、IL13和IFNγ则无相关性（P>0.05）。我们的数据表明，局部辅助性T细胞2（TH2）细胞因子反应在EOMA患者的脑脊液中占主导地位。T淋巴细胞与寄生虫相互作用的数据对于有效疫苗和免疫疗法的设计很重要。脑脊液中辅助性T细胞1（TH1）/TH2细胞因子的检测对于寄生虫相关性脑膜炎的诊断也可能具有一定潜力。