Gosnell William L, Kramer Kenton J
Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawa'i at Manoa, Honolulu, HI 96813 , USA.
Hawaii J Med Public Health. 2013 Jun;72(6 Suppl 2):49-51.
Human infection with the rat lungworm, Angiostrongylus cantonensis, is characterized by a vigorous eosinophil response that gives the disease its name, eosinophilic meningitis. The actual role eosinophils play, both protective and destructive, in this infectious process is still largely a mystery. Research since 2002 has indicated that eosinophils are a multifaceted granulocyte that contributes to a wide range of physiological and pathological processes depending on their location and activation status. This article suggests an expanded role for eosinophils as both classic antiparasitic effector cells and as immune regulatory cells in eosinophilic meningitis caused by Angiostrongylus cantonensis.
人类感染广州管圆线虫（鼠肺线虫）的特征是出现强烈的嗜酸性粒细胞反应，这种反应赋予了该疾病“嗜酸性粒细胞性脑膜炎”这一名称。嗜酸性粒细胞在这一感染过程中所起的保护和破坏作用，在很大程度上仍是个谜。自2002年以来的研究表明，嗜酸性粒细胞是一种多面性的粒细胞，根据其所处位置和激活状态，它会参与多种生理和病理过程。本文提出，嗜酸性粒细胞在由广州管圆线虫引起的嗜酸性粒细胞性脑膜炎中，作为经典的抗寄生虫效应细胞和免疫调节细胞，发挥着更为广泛的作用。
