无钾则无酸：钾离子通道与胃酸分泌
No potassium, no acid: K+ channels and gastric acid secretion.
作者信息
Heitzmann Dirk, Warth Richard
机构信息
Institute of Physiology, Regensburg, Germany.
出版信息
Physiology (Bethesda). 2007 Oct;22:335-41. doi: 10.1152/physiol.00016.2007.
PMID:17928547
Abstract
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
摘要
胃H⁺-K⁺-ATP酶将H⁺泵入管腔并同时摄取K⁺。在产酸的壁细胞中，管腔KCNE2/KCNQ1钾通道在补充管腔液中的K⁺方面起关键作用。KCNE2/KCNQ1通道失活可消除胃酸分泌并显著改变胃黏膜结构。
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