早幼粒细胞白血病核小体的结构、动力学及功能

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.

作者信息

Bernardi Rosa, Pandolfi Pier Paolo

机构信息

Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

出版信息

Nat Rev Mol Cell Biol. 2007 Dec;8(12):1006-16. doi: 10.1038/nrm2277.

DOI:10.1038/nrm2277

PMID:17928811

Abstract

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

摘要

早幼粒细胞白血病（PML）肿瘤抑制蛋白是PML核体（PML-NB）的典型代表，对于这种大分子核结构的正确组装至关重要。与其他更特殊的亚核结构如卡哈尔体和多梳蛋白复合体不同，PML-NB在功能上具有多效性，并参与多种细胞功能的调节。PML-NB是动态结构，有利于蛋白质的隔离和释放，介导其翻译后修饰，并在应对各种细胞应激时促进特定的核事件。最近的数据表明，PML-NB在组成、流动性和功能上可能存在异质性。