表面活性素C抑制猪肺炎支原体诱导的小鼠RAW 264.7细胞中促炎细胞因子的转录和一氧化氮的产生。
Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells.
作者信息
Hwang Mi-Hyun, Chang Zhi-Qiang, Kang Eun-Hee, Lim Jong-Hwan, Yun Hyo-In, Rhee Man-Hee, Jeong Kyu-Shik, Park Seung-Chun
机构信息
College of Veterinary Medicine, Kyungpook National University, 702-701 Daegu, Republic of Korea.
出版信息
Biotechnol Lett. 2008 Feb;30(2):229-33. doi: 10.1007/s10529-007-9552-x. Epub 2007 Oct 11.
Intact pathogenic Mycoplasma hyopneumoniae at 100 microg protein ml(-1) induced transcription of proinflammatory cytokines such as cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha, interleukin(IL)-1, IL-6 and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. After pretreatment with 50 microg surfactin C/ml, purified from Bacillus subtilis, transcription of the COX-2, IL-1beta, IL-6 and iNOS genes induced by M. hyopneumoniae was inhibited by 43%, 82%, 72% and 59%, respectively.
每毫升含100微克蛋白质的完整致病性猪肺炎支原体可诱导RAW 264.7细胞中促炎细胞因子的转录，如环氧合酶（COX）-2、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1、IL-6和诱导型一氧化氮合酶（iNOS）。用从枯草芽孢杆菌中纯化得到的每毫升50微克的表面活性素C进行预处理后，猪肺炎支原体诱导的COX-2、IL-1β、IL-6和iNOS基因的转录分别被抑制了43%、82%、72%和59%。
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