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[甲状腺与喉癌的关系]

[Thyroid gland involvement in cancer of the larynx].

作者信息

Croce A, Moretti A, Bianchedi M

机构信息

Università degli Studi di Chieti.

出版信息

Acta Otorhinolaryngol Ital. 1991 Jul-Aug;11(4):429-35.

PMID:1792897
Abstract

Numerous diseases that require surgical treatment often occur in the thyroid, one of the most important organs in the neck. An example of such pathologies are benign and malignant neoplasms. It is still not well known, however, if certain secondary malignant neoplasms may also arise there. While this pathology is relatively frequent, and often asymptomatic, the incidence of secondary lesions observed clinically in the thyroid is much lower than that found in series based on necroscopy. The thyroid may be involved by metastatic spreading of systemic malignant neoplasms (of the kidney, breasts, lung, colon, rectum, etc.) or by direct extension of laryngeal, hypopharyngeal or esophageal cancer, the latter being more frequent. In this paper the Authors report their experience with regard to the incidence of tumorous involvement of the thyroid in 23 patients (22 of which were males between the ages of 48 and 69--average age, 65) under observation for laryngeal cancer from 1986 to 1990. All the patients had an epidermoid carcinoma of the larynx that, due to its location and size, required a hemithyroidectomy or an isthmectomy associated with laryngectomy (20 total laryngectomies with hemithyroidectomies and 3 subtotal laryngectomies with isthmectomy). Upon pathologic examination, 7 thyroid specimens (30%) revealed tumorous involvement of the thyroid and in those cases of males who had undergone total laryngectomy with hemithyroidectomy, thyroid involvement was found. In 5 cases, tumorous involvement was immediately evident upon microscopic examination (1 case of solitary tumor metastasis and 4 of direct extension).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

许多需要手术治疗的疾病常发生在甲状腺,甲状腺是颈部最重要的器官之一。此类病症的例子包括良性和恶性肿瘤。然而,目前仍不清楚某些继发性恶性肿瘤是否也会在那里出现。虽然这种病理情况相对常见,且通常无症状,但临床上观察到的甲状腺继发性病变的发生率远低于基于尸检的系列研究中的发现。甲状腺可能会受到全身恶性肿瘤(如肾、乳腺、肺、结肠、直肠等)的转移扩散影响,或者受到喉癌、下咽癌或食管癌的直接蔓延影响,后者更为常见。在本文中,作者报告了他们对1986年至1990年期间因喉癌接受观察的23例患者(其中22例为48至69岁的男性,平均年龄65岁)甲状腺肿瘤累及发生率的经验。所有患者均患有喉表皮样癌,由于其位置和大小,需要进行半甲状腺切除术或与喉切除术相关的峡部切除术(20例全喉切除术加半甲状腺切除术,3例次全喉切除术加峡部切除术)。经病理检查,7份甲状腺标本(30%)显示有甲状腺肿瘤累及,在那些接受全喉切除术加半甲状腺切除术的男性病例中发现了甲状腺受累情况。在5例中,显微镜检查时肿瘤累及立即明显(1例为孤立性肿瘤转移,4例为直接蔓延)。(摘要截取自250字)

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