ATF2是一种双激活转录因子和DNA损伤反应蛋白。
ATF2 on the double - activating transcription factor and DNA damage response protein.
作者信息
Bhoumik Anindita, Lopez-Bergami Pablo, Ronai Ze'ev
机构信息
Signal Transduction Program, Burnham Institute for Medical Research, La Jolla, CA, USA.
出版信息
Pigment Cell Res. 2007 Dec;20(6):498-506. doi: 10.1111/j.1600-0749.2007.00414.x.
Abstract
Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.
摘要
信号转导通路在调控包括细胞存活与死亡在内的关键细胞过程中发挥着关键作用。越来越多的证据表明，在皮肤肿瘤发生和发展过程中会出现信号通路的变化。这些变化会影响包括转录因子在内的下游底物的活性。活化转录因子2（ATF2）与恶性和非恶性皮肤肿瘤的发生有关。ATF2分别通过JNK/p38或ATM/ATR对其磷酸化，从而介导转录和DNA损伤控制。在此，我们总结了目前对ATF2调控、功能及其在恶性和非恶性皮肤肿瘤发生中的作用的理解。
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