短吻海蛇（肖，1802年）毒液对Hep2和HeLa细胞体外增殖以及艾氏腹水癌肿瘤体内生长的抑制作用。
Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom.
作者信息
Karthikeyan R, Karthigayan S, Sri Balasubashini M, Somasundaram S T, Balasubramanian T
机构信息
Centre for Advanced Study in Marine Biology, Annamalai University, Parangipettai, 608 502, Tamil Nadu, India.
出版信息
Toxicon. 2008 Jan;51(1):157-61. doi: 10.1016/j.toxicon.2007.08.012. Epub 2007 Sep 2.
The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 microg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.
评估了海蛇（短尾海蛇）毒液对瑞士白化小鼠的艾氏腹水癌（EAC）以及HeLa和Hep2肿瘤细胞培养物的抗肿瘤活性。在测试的不同剂量中，发现24小时时6.50微克/毫升可有效抑制癌细胞增殖。通过腹腔注射给予荷EAC小鼠相同剂量可显著降低肿瘤生长，并且小鼠的寿命延长了201.25%，证明了这一点。
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