蛇毒在癌症治疗中的治疗潜力：当前观点
Therapeutic potential of snake venom in cancer therapy: current perspectives.
作者信息
Vyas Vivek Kumar, Brahmbhatt Keyur, Bhatt Hardik, Parmar Utsav
机构信息
Institute of Pharmacy, Nirma University, Ahmadabad 382 481 Gujarat, India.
出版信息
Asian Pac J Trop Biomed. 2013 Feb;3(2):156-62. doi: 10.1016/S2221-1691(13)60042-8.
Abstract
Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. There are many published studies describing and elucidating the anti-cancer potential of snake venom. Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species. Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes, affecting the migration and proliferation of these cells. Some of substances found in the snake venom present a great potential as anti-tumor agent. In this review, we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity.
摘要
动物产生的许多活性分泌物已被用于开发治疗高血压和癌症等疾病的新药。蛇毒毒素对许多医疗状况的治疗做出了重大贡献。有许多已发表的研究描述和阐明了蛇毒的抗癌潜力。癌症治疗是使用源自不同物种动物的蛋白质肽和酶的主要领域之一。蛇毒中的一些蛋白质、肽和酶在分离和评估时可能会特异性地结合癌细胞膜，影响这些细胞的迁移和增殖。蛇毒中发现的一些物质具有作为抗肿瘤剂的巨大潜力。在这篇综述中，我们展示了近年来涉及具有抗癌活性的蛇毒活性化合物的主要研究成果。
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