Benarroz M O, Fonseca A S, Rocha G S, Frydman J N G, Rocha V C, Pereira M O, Bernardo-Filho M
Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87, 4 Andar, Vila Isabel, 20551-030 Rio de Janeiro, RJ, Brazil.
Appl Radiat Isot. 2008 Feb;66(2):139-46. doi: 10.1016/j.apradiso.2007.08.004. Epub 2007 Aug 15.
Effects of Cinnamomum zeylanicum (cinnamon) on the labelling of blood constituents with technetium-99m(99mTc) and on the morphology of red blood cells were studied. Blood samples from Wistar rats were incubated with cinnamon extract for 1 hour or with 0.9% NaCl, as control. Labelling of blood constituents with 99mTc was performed. Plasma (P) and blood cells (BC), soluble (SF-P and SF-BC) and insoluble (IF-P and IF-BC) fractions were separated. The radioactivity in each fraction was counted and the percentage of radioactivity incorporated (%ATI) was calculated. Blood smears were prepared, fixed, stained and the qualitative and quantitative morphological analysis of the red blood cells was evaluated. The data showed that the cinnamon extract decreased significantly (p<0.05) the %ATI on BC, IF-P and IF-BC. No modifications were verified on shape of red blood cells. Cinnamon extracts could alter the labelling of blood constituents with 99mTc, and although our results were obtained with animals, precaution is suggested in interpretations of nuclear medicine examinations involving the labelling of blood constituents in patients who are using cinnamon.
研究了锡兰肉桂对用锝-99m（99mTc）标记血液成分以及对红细胞形态的影响。将来自Wistar大鼠的血样与肉桂提取物孵育1小时，或与作为对照的0.9%氯化钠孵育。用99mTc对血液成分进行标记。分离血浆（P）和血细胞（BC）、可溶性部分（SF-P和SF-BC）和不溶性部分（IF-P和IF-BC）。对每个部分的放射性进行计数，并计算掺入的放射性百分比（%ATI）。制备血涂片，固定、染色，并对红细胞进行定性和定量形态分析。数据显示，肉桂提取物显著降低了（p<0.05）BC、IF-P和IF-BC上的%ATI。未观察到红细胞形状的改变。肉桂提取物可能会改变用99mTc对血液成分的标记，尽管我们的结果是在动物身上获得的，但对于使用肉桂的患者进行涉及血液成分标记的核医学检查时，在解释结果时建议谨慎。
