[Kinetic mechano-chemical model of a muscle with a six-stage cross-bridge cycle].

A kinetic scheme of the mechano-chemical cycle of the cross-bridges and a mathematical model based on this scheme are proposed. The main assumptions accepted in the scheme are: the step of the inorganic phosphate release precedes the force-generating step of a cross-bridge; the rate-limiting step of the ATP hydrolysis is isomerization of the actomyosin-ADP complex. It is shown that the model well describes the mechanical and biochemical transients initiated by the temperature jump and flash photolysis of the caged compounds in skinned muscle fibres.