Wei Benjamin P C, Robins-Browne Roy M, Shepherd Robert K, Azzopardi Kristy, Clark Graeme M, O'Leary Stephen J
Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisbourne St, East Melbourne, Victoria 3002, Australia.
Arch Otolaryngol Head Neck Surg. 2007 Oct;133(10):987-94. doi: 10.1001/archotol.133.10.987.
To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation.
Interventional animal study.
Thirty-six rats (18 immunized and 18 unimmunized) received cochlear implantations and were then infected with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) in numbers sufficient to induce meningitis.
The rats with implants that received PPV23 were protected from meningitis when the bacteria were delivered via the hematogenous and middle-ear routes (Fisher exact test P<.05). However, the protective effect of the vaccine in the rats with implants was only moderate when the bacteria were inoculated directly into the inner ear.
Our animal model clearly demonstrates that immunization can protect healthy rats with a cochlear implant from meningitis caused by a vaccine-covered serotype. This finding supports the notion that all current and future implant recipients should be vaccinated against S pneumoniae.
研究23价肺炎球菌荚膜多糖疫苗（PPV23）是否能降低健康大鼠人工耳蜗植入后发生脑膜炎的风险。
干预性动物研究。
36只大鼠（18只免疫接种，18只未免疫接种）接受人工耳蜗植入，然后通过3种不同途径（血行、中耳和内耳）感染肺炎链球菌，感染数量足以诱发脑膜炎。
接种PPV23的植入大鼠在细菌通过血行和中耳途径传播时可预防脑膜炎（Fisher确切概率检验P<0.05）。然而，当将细菌直接接种到内耳时，疫苗对植入大鼠的保护作用仅为中等程度。
我们的动物模型清楚地表明，免疫接种可保护植入人工耳蜗的健康大鼠免受疫苗覆盖血清型引起的脑膜炎。这一发现支持了所有当前及未来的植入接受者都应接种肺炎链球菌疫苗的观点。
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