核磷蛋白/B23的致癌作用。
Oncogenic role of nucleophosmin/B23.
作者信息
Yung Benjamin Yat Ming
机构信息
Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
出版信息
Chang Gung Med J. 2007 Jul-Aug;30(4):285-93.
Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.
核仁磷酸蛋白/B23最初被鉴定为一种在癌细胞中比正常细胞表达水平更高的核仁蛋白。长期以来，人们一直认为核仁磷酸蛋白/B23在肿瘤形成中起作用。在过去15年里，经过我们和其他人的努力，已证明核仁磷酸蛋白/B23具有致癌作用。在这篇综述中，我们提供的证据表明核仁磷酸蛋白/B23可能是调节癌症生长的关键基因，并探讨核仁磷酸蛋白/B23如何促进肿瘤发生。
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