Daly Farrah N, Schiff David
University of Virginia Health System, Neuro-Oncology Center, Box 800432, Charlottesville, VA 22908-0432, USA.
Expert Rev Neurother. 2007 Oct;7(10):1327-36. doi: 10.1586/14737175.7.10.1327.
Management issues for patients with brain tumors include peritumoral edema, symptomatic seizures, venous thromboembolism, headache, pain, fatigue and neuropsychological complaints. Vasogenic edema is typically ameliorated with the lowest dose possible of corticosteroid. Seizures are managed with attention to additional or complicated side effects of antiepileptic drugs and their interactions with chemotherapy, and primary prevention with antiepileptic medications is not recommended. Appropriate treatments for headache, pain, fatigue and neuropsychological complaints are important, but are not yet well standardized. Above all, patients' personal goals regarding their priorities at the end of life have the most importance.
脑肿瘤患者的管理问题包括瘤周水肿、症状性癫痫、静脉血栓栓塞、头痛、疼痛、疲劳和神经心理学方面的主诉。血管源性水肿通常采用尽可能低剂量的皮质类固醇进行改善。癫痫的管理需关注抗癫痫药物的额外或复杂副作用及其与化疗的相互作用,不建议使用抗癫痫药物进行一级预防。针对头痛、疼痛、疲劳和神经心理学方面主诉的适当治疗很重要,但尚未得到很好的标准化。最重要的是,患者关于生命末期优先事项的个人目标最为重要。