The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, 27710, USA.
J Neurooncol. 2011 Jan;101(1):155-9. doi: 10.1007/s11060-010-0239-0. Epub 2010 Jun 4.
Striae distensae (stretch marks) are a common complication seen in patients on chronic corticosteroid therapy. Under certain circumstances, primary brain tumor patients require chronic corticosteroid therapy and can suffer from striae distensae. Bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor-A (VEGF-A) is now more widely used for the treatment of primary brain tumors. In this paper, we present four cases of ulcerated striae distensae in primary brain tumor patients on concurrent corticosteroid and bevacizumab therapy. Because of bevacizumab's effects on wound healing and its recent accelerated approval for recurrent glioblastoma multiforme (GBM), the most common malignant primary brain tumor in adults, this novel skin complication should be considered in patients on concurrent corticosteroid and bevacizumab therapy.
膨胀纹（伸展纹）是接受慢性皮质类固醇治疗的患者中常见的并发症。在某些情况下，原发性脑肿瘤患者需要接受慢性皮质类固醇治疗，并且可能会出现膨胀纹。贝伐单抗是人血管内皮生长因子-A（VEGF-A）的一种人源化单克隆抗体，现已更广泛地用于治疗原发性脑肿瘤。在本文中，我们介绍了 4 例同时接受皮质类固醇和贝伐单抗治疗的原发性脑肿瘤患者出现溃疡性膨胀纹的病例。由于贝伐单抗对伤口愈合的影响，以及其最近加速批准用于成人中最常见的恶性原发性脑肿瘤多形性胶质母细胞瘤（GBM），因此在同时接受皮质类固醇和贝伐单抗治疗的患者中应考虑这种新的皮肤并发症。
