Atef Ahmed, Fawaz Ahmed Aly
Department of Otorhinolaryngology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Eur Arch Otorhinolaryngol. 2008 May;265(5):571-4. doi: 10.1007/s00405-007-0479-6. Epub 2007 Oct 17.
Pain control in pediatric patients undergoing tonsillectomy remains a dilemma. Tramadol is reported to be an effective analgesic. This prospective, double-blinded, placebo-controlled study was performed to evaluate the analgesic efficacy and safety of submucosal infiltration of tramadol on postoperative pain in children after standard bipolar diathermy tonsillectomy. Following standard bipolar diathermy tonsillectomy was performed, 40 patients were randomized to receive submucoasl infiltration with 2 mg kg(-1) tramadol in 3 ml of normal saline (1.5 ml per tonsil) or normal saline only. The patients in each group were compared postoperatively with regard to the quality of pain control using the objective pain scale (OPS), sedation score and their analgesic requirements. Peritonsillar infiltration of tramadol (group 2) provided superior postoperative analgesia to placebo (group 1) for 4 h after surgery. In addition, group 1 received significantly more doses of paracetamol than group 2 in order to maintain analgesia in the first 12 h after recovery from anesthesia. Peritonsillar infiltration of tramadol appears to be an effective method of providing superior analgesia in the postoperative period when compared to placebo.
扁桃体切除术后小儿患者的疼痛控制仍然是一个难题。据报道,曲马多是一种有效的镇痛药。本前瞻性、双盲、安慰剂对照研究旨在评估曲马多黏膜下浸润对标准双极电凝扁桃体切除术后儿童术后疼痛的镇痛效果和安全性。在进行标准双极电凝扁桃体切除术后,40例患者被随机分为两组,一组接受在3毫升生理盐水中加入2毫克/千克曲马多的黏膜下浸润(每侧扁桃体1.5毫升),另一组仅接受生理盐水。术后比较两组患者使用客观疼痛量表(OPS)评估的疼痛控制质量、镇静评分及其镇痛需求。曲马多扁桃体周浸润组(第2组)术后4小时的镇痛效果优于安慰剂组(第1组)。此外,为了在麻醉苏醒后的前12小时维持镇痛,第1组比第2组显著更多地使用了对乙酰氨基酚。与安慰剂相比,曲马多扁桃体周浸润似乎是术后提供更好镇痛效果的有效方法。