Gönül Onur, Satılmış Tülin, Bayram Ferit, Göçmen Gökhan, Sipahi Aysegül, Göker Kamil
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Marmara University, Istanbul, Turkey.
Head Face Med. 2015 Oct 14;11:35. doi: 10.1186/s13005-015-0090-9.
The aim of this study was to evaluate the effectiveness of submucosal application of tramadol, for acute postoperative facial pain, following the extraction of impacted third molar teeth. This prospective, double-blind, randomised placebo-controlled study included 60 ASA I-II patients undergoing impacted third molar surgery under local anaesthesia. Following the surgical procedure, patients were randomly divided into two groups; group T (1 mg/kg tramadol) and group S (2-mL saline). Treatments were applied submucosally after surgery. Pain after extraction was evaluated using a visual analogue scale (VAS) 0.5, 1, 2, 4, 6, 12, 24, and 48 h postoperatively. The time at which the first analgesic drug was taken, the total analgesic dose used, and adverse tissue reactions were also evaluated. In group T, postoperative VAS scores were significantly lower compared to that in group S (p < 0.05). This study demonstrated that post-operative submucosal application of tramadol is an effective method for reducing acute post-operative facial pain after impacted third molar surgery.
本研究的目的是评估曲马多黏膜下给药对阻生第三磨牙拔除术后急性面部疼痛的疗效。这项前瞻性、双盲、随机安慰剂对照研究纳入了60例在局部麻醉下接受阻生第三磨牙手术的ASA I-II级患者。手术结束后，患者被随机分为两组；T组（1mg/kg曲马多）和S组（2mL生理盐水）。术后在黏膜下进行治疗。术后0.5、1、2、4、6、12、24和48小时使用视觉模拟量表（VAS）评估拔牙后的疼痛情况。还评估了首次服用镇痛药物的时间、使用的总镇痛剂量以及不良组织反应。与S组相比，T组术后VAS评分显著更低（p＜0.05）。本研究表明，曲马多术后黏膜下给药是减轻阻生第三磨牙手术后急性面部疼痛的有效方法。
