Hutchinson Karen L, Rollin Pierre E
Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
J Infect Dis. 2007 Nov 15;196 Suppl 2:S357-63. doi: 10.1086/520611.
The size and duration of the 2000 outbreak of Sudan Ebola virus (SEBOV) infection in Uganda made it possible to collect serial serum samples from 87 patients (53 survivors and 34 nonsurvivors). Surprisingly, the levels of tumor necrosis factor- alpha and interferon (IFN)- gamma , which had been found to be increased in patients with fatal Zaire Ebola virus infection, were not increased in any of the patients with SEBOV infection. The levels of interleukin (IL)-1 beta , IFN- gamma -inducible protein-10, and RANTES (regulated on activation, normally T cell-expressed and -secreted) were higher in samples from all patients with SEBOV infection than in control samples from healthy hospital staff members, but their levels did not differ between those who survived and those who did not. The levels of IFN- alpha were significantly higher in surviving patients with SEBOV infection, whereas the levels of IL-6, IL-8, IL-10, and macrophage inflammatory protein-1 beta were higher in patients with fatal SEBOV infections.
2000年乌干达爆发的苏丹埃博拉病毒（SEBOV）感染规模和持续时间，使得研究人员有可能从87名患者（53名幸存者和34名非幸存者）身上采集系列血清样本。令人惊讶的是，在致命的扎伊尔埃博拉病毒感染患者中发现升高的肿瘤坏死因子-α和干扰素（IFN）-γ水平，在任何SEBOV感染患者中均未升高。白细胞介素（IL）-1β、IFN-γ诱导蛋白-10和调节激活正常T细胞表达和分泌因子（RANTES）的水平，在所有SEBOV感染患者的样本中均高于健康医院工作人员的对照样本，但幸存者和非幸存者之间这些水平并无差异。SEBOV感染存活患者的IFN-α水平显著更高，而致命SEBOV感染患者的IL-6、IL-8、IL-10和巨噬细胞炎性蛋白-1β水平更高。
