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阿尔茨海默病中的选择性命名(及理解)缺陷?

Selective naming (and comprehension) deficits in Alzheimer's disease?

作者信息

Masterson Jackie, Druks Judit, Kopelman Michael, Clare Linda, Garley Claire, Hayes Maureen

机构信息

Psychology and Human Development, Institute of Education, University of London, UK.

出版信息

Cortex. 2007 Oct;43(7):921-34. doi: 10.1016/s0010-9452(08)70691-9.

Abstract

The study addresses the issue of the selective preservation of verbs in Alzheimer's disease (AD). Twenty three AD patients and age-matched controls named pictures of objects and actions and took part in a word-picture verification task. The results for picture naming revealed that both patients and controls were faster and produced more target responses for objects than actions. In the comprehension task, accuracy levels were comparable for nouns and verbs, but response times were longer for verbs. Although patients were more error prone and had longer latencies in both tasks than controls, the only qualitative difference in performance between the groups was in response to trials with semantically related foils in the word-picture verification task. Patients were particularly error prone in this condition. We conclude that the results do not provide support for the notion that verbs are selectively preserved in AD. They also do not provide conclusive evidence for claims that depressed naming and comprehension is (always) due to loss of semantic knowledge or inadequate access to semantic knowledge. Finally, we discuss the findings in relation to comparable investigations in patients with semantic dementia.

摘要

这项研究探讨了阿尔茨海默病(AD)中动词的选择性保留问题。23名AD患者和年龄匹配的对照组对物体和动作的图片进行命名,并参与了一项单词 - 图片验证任务。图片命名的结果显示,患者和对照组对物体的反应都比对动作更快,且产生的目标反应更多。在理解任务中,名词和动词的准确率相当,但动词的反应时间更长。尽管患者在两项任务中比对照组更容易出错且潜伏期更长,但两组在表现上唯一的质的差异在于单词 - 图片验证任务中对语义相关干扰项的试验反应。在这种情况下,患者特别容易出错。我们得出结论,这些结果不支持动词在AD中被选择性保留的观点。它们也没有为抑郁的命名和理解(总是)归因于语义知识丧失或语义知识获取不足的说法提供确凿证据。最后,我们结合对语义性痴呆患者的类似研究讨论了这些发现。

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