Griffiths E K, Schapira D V
Mease Health Care and Manning Foundation, Dunedin, FL.
Cancer Detect Prev. 1991;15(4):303-5.
A group of 531 participants age 50 years or older were evaluated for colonic polyps and malignancy with stool occult blood testing, hemoglobin, hematocrit, serum ferritin, flexible fiberoptic sigmoidoscopy, and colonoscopy. Screening revealed 1 colorectal cancer, 2 malignant polyps, 30 hyperplastic polyps, 69 adenomatous polyps, 4 villous adenomas, and 2 villous components. Low serum ferritin, an indicator of iron deficiency without anemia, improved the detection of colonic malignancies and polyps when used in combination with stool occult blood testing. The program was acceptable to participants and attrition was low; the attrition rate for the screening program at 1 year was 14.5%.
对一组531名50岁及以上的参与者进行了结肠息肉和恶性肿瘤评估，评估方法包括粪便潜血试验、血红蛋白、血细胞比容、血清铁蛋白、纤维乙状结肠镜检查和结肠镜检查。筛查发现1例结直肠癌、2例恶性息肉、30例增生性息肉、69例腺瘤性息肉、4例绒毛状腺瘤和2例绒毛成分。低血清铁蛋白是无贫血缺铁的指标，与粪便潜血试验联合使用时可提高结肠恶性肿瘤和息肉的检出率。该项目为参与者所接受，损耗率较低；筛查项目1年时的损耗率为14.5%。
