Yamagami S, Mui K, Hirayama E, Furutsuka D, Soma T, Soejima S, Nishiwaki S, Kiriike N, Boku S
Department of Neuropsychiatry, Osaka City University Medical School, Japan.
Drugs Exp Clin Res. 1991;17(4):217-23.
The effect of bifemelane hydrochloride on dementia in the elderly was studied in thirty-one patients having cerebrovascular disorders. Alzheimer's disease, Parkinsonism and related diseases. The drug (150 mg) was administered orally three times daily for 10 weeks. The final global improvement rating was 77.4% for all patients. The rates of improvement for Alzheimer's disease were higher than those for cerebrovascular disorders, suggesting that this drug affects Alzheimer's disease through a cholinergic potentiating action. Psychotic, neurological and subjective symptoms, and the activity of daily life, were rated before, during and after treatment. All mean rates of improvement were based on observations made in the 4th week after the start of treatment. Improvement rates for global symptoms were more than 80% for emotional incontinence and prejudice or querulous attitudes toward the nurses, and in headache, tinnitus and dizziness among the subjective symptoms. The improvement in intellectual function was evaluated by the dementia rating scale for the elderly (DRSE), and a significant increase was found in DRSE after treatment with this drug. Side effects attributable to the drug were noted in one patient developing urticaria. It is thus suggested that bifemelane hydrochloride is useful in the treatment of different symptoms of dementia.
对31例患有脑血管疾病、阿尔茨海默病、帕金森病及相关疾病的老年患者，研究了盐酸比呋美林对老年痴呆的疗效。该药物（150毫克）每日口服3次，持续10周。所有患者的最终整体改善率为77.4%。阿尔茨海默病的改善率高于脑血管疾病，表明该药物通过增强胆碱能作用影响阿尔茨海默病。在治疗前、治疗期间和治疗后，对精神病性、神经学和主观症状以及日常生活活动进行评分。所有平均改善率均基于治疗开始后第4周的观察结果。整体症状的改善率在情绪失禁、对护士的偏见或抱怨态度方面超过80%，在主观症状中的头痛、耳鸣和头晕方面也是如此。通过老年痴呆评定量表（DRSE）评估智力功能的改善情况，使用该药物治疗后DRSE有显著提高。有1例患者出现荨麻疹，记录到与该药物相关的副作用。因此，提示盐酸比呋美林对治疗痴呆的不同症状有效。
