由γ-（苯硒基）烷基芳基磺酰胺立体控制合成取代的N-芳基磺酰基氮杂环丁烷。

Stereocontrolled synthesis of substituted N-arenesulfonyl azetidines from gamma-(phenylseleno)alkyl arylsulfonamides.

作者信息

Tiecco Marcello, Testaferri Lorenzo, Temperini Andrea, Terlizzi Raffaella, Bagnoli Luana, Marini Francesca, Santi Claudio

机构信息

Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università di Perugia, I-06123, Perugia, Italy.

出版信息

Org Biomol Chem. 2007 Nov 7;5(21):3510-9. doi: 10.1039/b712861d. Epub 2007 Sep 21.

DOI:10.1039/b712861d

PMID:17943211

Abstract

Different synthetic methodologies for the stereocontrolled synthesis of substituted azetidines are reported. The approach utilizes an optimized oxidation reaction of gamma-(phenylseleno)alkyl arylsulfonamides, followed by the intramolecular substitution of the resulting phenylselenonyl group by the nitrogen atom.

摘要

报道了用于立体控制合成取代氮杂环丁烷的不同合成方法。该方法利用γ-（苯基硒基）烷基芳基磺酰胺的优化氧化反应，然后通过氮原子对所得苯基硒酰基进行分子内取代。