用于与皮肤和骨骼整合的多孔复合假体支柱
Porous composite prosthetic pylon for integration with skin and bone.
作者信息
Pitkin Mark, Raykhtsaum Grigory, Pilling John, Galibin Oleg V, Protasov Mikhail V, Chihovskaya Julie V, Belyaeva Irina G, Blinova Miralda I, Yudintseva Natalia M, Potokin Igor L, Pinaev George P, Moxson Vladimir, Duz Volodimir
机构信息
Tufts University, Boston, MA, USA.
出版信息
J Rehabil Res Dev. 2007;44(5):723-38. doi: 10.1682/jrrd.2006.12.0160.
This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.
本文介绍了“皮肤与骨骼一体化支腿”（SBIP-1）进一步开发和测试的结果，该支腿用于将残余骨骼与外部肢体假体进行经皮（穿过皮肤）连接。我们使用数学建模和力学测试研究了一种由钛颗粒和细金属丝制成的复合结构（称为SBIP-2）。结果表明，支腿的强度与解剖学骨骼相当。对30只大鼠进行的体外和体内动物研究表明，复合支腿的加固并未损害其先前显示的吸引皮肤和骨细胞通过该装置向内生长的能力。这些发现为从假体装置向身体安全可靠地长期经皮传输重要和治疗性物质、信号以及必要的力和力矩提供了证据。
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