Pitkin Mark, Raykhtsaum Grigory, Pilling John, Shukeylo Yuri, Moxson Vladimir, Duz Volodimir, Lewandowski John, Connolly Raymond, Kistenberg Robert S, Dalton John F, Prilutsky Boris, Jacobson Stewart
Tufts University School of Medicine, Physical Medicine and Rehabilitation, Boston, MA 02111, USA.
J Rehabil Res Dev. 2009;46(3):315-30. doi: 10.1682/jrrd.2008.09.0123.
This article presents recent results in the development of the skin and bone integrated pylon (SBIP) intended for direct skeletal attachment of limb prostheses. In our previous studies of the porous SBIP-1 and SBIP-2 prototypes, the bond site between the porous pylons and residuum bone and skin did not show the inflammation characteristically observed when solid pylons are used. At the same time, porosity diminished the strength of the pylon. To find a reasonable balance between the biological conductivity and the strength of the porous pylon, we developed a mathematical model of the composite permeable structure. A novel manufacturing process was implemented, and the new SBIP-3 prototype was tested mechanically. The minimal strength requirements established earlier for the SBIP were exceeded threefold. The first histopathological analysis of skin, bone, and the implanted SBIP-2 pylons was conducted on two rats and one cat. The histopathological analysis provided new evidence of inflammation-free, deep ingrowth of skin and bone cells throughout the SBIP structure.
本文介绍了用于肢体假肢直接骨骼附着的皮肤与骨骼一体化桩柱（SBIP）的最新研发成果。在我们之前对多孔SBIP - 1和SBIP - 2原型的研究中，多孔桩柱与残端骨骼及皮肤之间的结合部位未表现出使用实心桩柱时特有的炎症反应。同时，孔隙率降低了桩柱的强度。为了在多孔桩柱的生物传导性和强度之间找到合理的平衡，我们建立了复合渗透结构的数学模型。实施了一种新颖的制造工艺，并对新的SBIP - 3原型进行了力学测试。该原型的强度超过了此前为SBIP设定的最低强度要求的三倍。对两只大鼠和一只猫进行了首次关于皮肤、骨骼以及植入的SBIP - 2桩柱的组织病理学分析。组织病理学分析提供了新的证据，表明皮肤和骨骼细胞在整个SBIP结构中无炎症地深入生长。
