Portnova G V, Sysoeva O V, Maliuchenko N V, Timofeeva M A, Kulikova M A, Tonevitskiĭ A G, Kirpichnikov M P, Ivanitskiĭ A M
Zh Vyssh Nerv Deiat Im I P Pavlova. 2007 Jul-Aug;57(4):450-60.
The association between the subjective time perception and polymorphism of some genes, regulating activity of serotonin and dopamine, was studied in 89 synchronized swimmers. COMT gene, responsible for dopamine destruction, influences on reproduction of short time intervals (1-2 s). 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow. 5-HTT and COMT genes, regulating activity of serotonin and dopamine respectively, are related with accuracy of orientation in time. Association of time perception with different genes and mediators suggests different perception mechanisms, in different time ranges, in concordance with the previous physiological studies. The current study reveals that these physiological mechanisms have different molecular-neurochemical basis that helps to overcome the gap between the investigation on systemic and molecular levels.
在89名花样游泳运动员中研究了主观时间感知与某些调节血清素和多巴胺活性的基因多态性之间的关联。负责多巴胺破坏的COMT基因影响短时间间隔(1 - 2秒)的重现。调节血清素活性的5-HT2A和MAOA基因影响主观时间流逝。分别调节血清素和多巴胺活性的5-HTT和COMT基因与时间定向准确性有关。时间感知与不同基因和介质的关联表明,与先前的生理学研究一致,在不同时间范围内存在不同的感知机制。当前研究表明,这些生理机制具有不同的分子神经化学基础,这有助于弥合系统水平和分子水平研究之间的差距。