Akhmirov Rauf, Mitiureva Dina, Zaichenko Maria, Smirnov Kirill, Sysoeva Olga
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117465 Moscow, Russia.
Center for Cognitive Sciences, Sirius University of Science and Technology, 354340 Sirius, Russia.
Int J Mol Sci. 2024 Dec 11;25(24):13305. doi: 10.3390/ijms252413305.
Time perception is a fundamental cognitive function essential for adaptive behavior and shared across species. The neural mechanisms underlying time perception, particularly its neuromodulation, remain debated. In this review, we examined the role of the serotonergic system in time perception (at the scale of seconds and minutes), building a translational bridge between human and non-human animal studies. The literature search was conducted according to the PRISMA statement in PubMed, APA PsycINFO, and APA PsycARTICLES. Sixty papers were selected for full-text review, encompassing both human (n = 10) and animal studies (n = 50). Summarizing the reviewed literature, we revealed consistent evidence for the role of serotonin in timing behavior, highlighting its complex involvement across retrospective, immediate, and prospective timing paradigms. Increased serotonergic activation appears to accelerate internal time speed, which we interpret through the dual klepsydra model as accelerated discharge of the temporal accumulator. However, some findings challenge this framework. Additionally, we link impulsivity-associated with decreased serotonergic functioning in our review-to a slower internal time speed. Variability in prospective timing tasks underscores the need for further research into how serotonin modulates reward-based temporal decisions, using novel approaches to disentangle internal time speed, response inhibition, and other factors.
时间感知是一种基本的认知功能，对适应性行为至关重要且在物种间具有共性。时间感知背后的神经机制，尤其是其神经调节作用，仍存在争议。在本综述中，我们研究了血清素能系统在时间感知（秒和分钟尺度）中的作用，在人类和非人类动物研究之间搭建了一座转化桥梁。文献检索按照PRISMA声明在PubMed、APA PsycINFO和APA PsycARTICLES中进行。筛选出60篇论文进行全文审查，包括人类研究（n = 10）和动物研究（n = 50）。总结所审查的文献，我们发现了血清素在计时行为中作用的一致证据，突出了其在回顾性、即时性和前瞻性计时范式中的复杂参与。血清素能激活增加似乎会加快内部时间速度，我们通过双漏壶模型将其解释为时间累加器的放电加速。然而，一些研究结果对这一框架提出了挑战。此外，在我们的综述中，我们将与血清素功能降低相关的冲动性与较慢的内部时间速度联系起来。前瞻性计时任务的变异性凸显了有必要使用新方法来区分内部时间速度响应抑制和其他因素，进一步研究血清素如何调节基于奖励的时间决策。
