Xu Hai-xing, Liu Xiao-ping, Gong Yun-xia
Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
Zhong Yao Cai. 2007 Jul;30(7):861-2.
To extract volatile oil from Shiquandabu pills and study technological process of its inclusion compound with beta-Cyclodextrin (beta-CD) to improve its stability.
The study was carried out with steam distillation and orthogonal design. The process conditions were studied by determining the utilization and ratio of oil from Shiquandabu pills volatile oil and extract ratio of in-clusion compound. The most important factor was the ratio of oil to beta-CD. and the inclusion compound was identified by FT-IR spectra and XRD.
The optimum preparation conditions for inclusion were best-established as oil: beta-CD was 1:8, the inclusion time and temperature were for 1.0 hours. at 20 degrees C.
Tne method can be used for increasing volatile oil's stability and its solubility. It is suitable for production of medicinal preparation.
提取十全大补丸中的挥发油,并研究其与β-环糊精(β-CD)包合物的工艺,以提高其稳定性。
采用水蒸气蒸馏法和正交设计进行研究。通过测定十全大补丸挥发油的利用率、出油率及包合物的得率来考察工艺条件。其中最重要的因素是油与β-CD的比例,并用傅里叶变换红外光谱(FT-IR)和X射线衍射(XRD)对包合物进行鉴定。
确定包合的最佳工艺条件为油与β-CD的比例为1:8,包合时间为1.0小时,温度为20℃。
该方法可用于提高挥发油的稳定性和溶解度,适用于药物制剂的生产。