假牙性口炎念珠菌分离株的体外抗真菌药敏性
Susceptibility of candida isolates from denture-related stomatitis to antifungal agents in vitro.
作者信息
Dorocka-Bobkowska Barbara, Konopka Krystyna
机构信息
Department of Prosthetic Dentistry, Poznan University of Medical Sciences, Poland.
出版信息
Int J Prosthodont. 2007 Sep-Oct;20(5):504-6.
The aim of this study was to determine the susceptibility of Candida isolates obtained from patients with Candida-associated denture stomatitis to 4 antimycotics. Antifungal susceptibility was assayed using the ATB-Fungus-2INT test. A total of 120 Candida strains were identified: C albicans (59.2%), C glabrata (20%), C tropicalis (12.5%), and C parapsilosis (8.3%). Amphotericin B, 5-fluorocytosine, fluconazole, and itraconazole were effective against 100%, 98.6%, 88.7%, and 87.3% of C albicans and 79.6%, 77.6%, 71.4%, and 79.6% of the other Candida strains, respectively. The identification of candidal strains and determination of their susceptibility to antifungals may improve the management of Candida-associated denture stomatitis.
本研究的目的是确定从念珠菌相关性义齿性口炎患者中分离出的念珠菌对4种抗真菌药物的敏感性。使用ATB-Fungus-2INT试验测定抗真菌药敏性。共鉴定出120株念珠菌菌株：白色念珠菌（59.2%）、光滑念珠菌（20%）、热带念珠菌（12.5%）和近平滑念珠菌（8.3%）。两性霉素B、5-氟胞嘧啶、氟康唑和伊曲康唑分别对100%、98.6%、88.7%和87.3%的白色念珠菌以及79.6%、77.6%、71.4%和79.6%的其他念珠菌菌株有效。念珠菌菌株的鉴定及其对抗真菌药物敏感性的测定可能会改善念珠菌相关性义齿性口炎的治疗。
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