黏膜移植物抗宿主病

Mucosal graft-vs-host disease.

作者信息

Lew J, Smith J A

机构信息

Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA.

出版信息

Oral Dis. 2007 Nov;13(6):519-29. doi: 10.1111/j.1601-0825.2007.01412.x.

DOI:10.1111/j.1601-0825.2007.01412.x

PMID:17944667

Abstract

Graft-vs-host disease (GVHD) is a serious complication of hematopoietic stem cell transplantation (HSCT). Indications for HSCT have greatly expanded, and more patients are undergoing HSCT today than ever before. In addition, the options for immunosuppressive therapy for both prevention and treatment of GVHD have also expanded. These changes have in turn altered the landscape of this disease. We have reviewed the current literature on this subject and presented an update on this disease with a particular emphasis on mucosal manifestations.

摘要

移植物抗宿主病（GVHD）是造血干细胞移植（HSCT）的一种严重并发症。HSCT的适应症已大幅扩展，如今接受HSCT的患者比以往任何时候都多。此外，用于预防和治疗GVHD的免疫抑制疗法选择也有所增加。这些变化反过来改变了这种疾病的格局。我们回顾了关于该主题的当前文献，并对这种疾病进行了更新，特别强调了黏膜表现。