Bos-den Braber Jacolien, Potting Carin M J, Bronkhorst Ewald M, Huysmans Marie-Charlotte D N J M, Blijlevens Nicole M A
Radboudumc, Nijmegen, Netherlands,
Support Care Cancer. 2015 Jan;23(1):13-9. doi: 10.1007/s00520-014-2297-x. Epub 2014 Jun 8.
Little is known about the understanding of the oral and dental needs of haematopoietic stem cell transplant (HSCT) patients or about dentists' views and experiences regarding this patient group. This information is essential if we want to improve the standard of peri-HSCT dental care. The primary objective of this qualitative survey was to explore the following: (1) The understanding of dental care pre- and post-HSCT (2) The subjective oral complaints of HSCT patients both short- and long-term (3) The relationship of these oral complaints to the severity of oral mucositis during hospitalization The secondary objective was to explore the opinions of dentists regarding dental care before and after HSCT.
All adult patients who survived HSCT at the Radboud University Medical Centre between 2010 and 2011 (n = 101) received a questionnaire. During hospitalization, mucositis scores were recorded daily in the patient's chart. The patients' dentist (n = 88) was also sent a questionnaire after permission of the patient.
Ninety-six out of 101 patients (95%) responded. The average period since HSCT was 19 months (range 8-31 months). The overall mean maximum mucositis score was 6.6 (sd = 3.3). Only eight patients reported not having visited a dentist pre-HSCT. The majority of the patients (59%) reported short-term oral complaints, and 28% reported long-term oral complaints. Fifty-two dentists responded (59%). Nine had not performed pre-HSCT screening and eight dentists reported screening their patients but could not complete the necessary treatments. Only 44 dentists succeeded in completing the required treatments. The most important advice of the dentist was to reinforce the importance of regular dental care.
Most patients report short-term and/or long-term oral complaints after HSCT. Most dentists stress the importance of regular dental care before and after HSCT but report not being familiar with the particular dental care needs of this patient group. The high response rate and the high rate of HSCT-related oral complaints emphasize the need of further research in this area.
对于造血干细胞移植（HSCT）患者口腔和牙齿需求的了解，以及牙医对该患者群体的看法和经验，我们知之甚少。如果我们想要提高HSCT围手术期牙科护理的标准，这些信息至关重要。这项定性调查的主要目的是探究以下内容：（1）对HSCT前后牙科护理的理解；（2）HSCT患者短期和长期的主观口腔不适；（3）这些口腔不适与住院期间口腔黏膜炎严重程度的关系。次要目的是探究牙医对HSCT前后牙科护理的看法。
2010年至2011年间在拉德堡德大学医学中心接受HSCT且存活的所有成年患者（n = 101）均收到一份问卷。住院期间，每天在患者病历中记录黏膜炎评分。在获得患者许可后，也向患者的牙医（n = 88）发送了问卷。
101名患者中有96名（95%）做出回应。HSCT后的平均时间为19个月（范围8 - 31个月）。总体平均最大黏膜炎评分为6.6（标准差 = 3.3）。只有8名患者报告在HSCT前未看过牙医。大多数患者（59%）报告有短期口腔不适，28%报告有长期口腔不适。52名牙医做出回应（59%）。9名牙医未进行HSCT前筛查，8名牙医报告对患者进行了筛查但无法完成必要治疗。只有44名牙医成功完成了所需治疗。牙医最重要的建议是强化定期牙科护理的重要性。
大多数患者在HSCT后报告有短期和/或长期口腔不适。大多数牙医强调HSCT前后定期牙科护理的重要性，但报告不熟悉该患者群体特殊的牙科护理需求。高回应率和与HSCT相关的口腔不适的高发生率强调了该领域进一步研究的必要性。
