Gorman Dennis M, Conde Eugenia
Department of Epidemiology & Biostatistics, Texas A&M Health Science Center, School of Rural Public Health, TAMU 1266, College Station, TX 77843-1266, USA.
Eval Program Plann. 2007 Nov;30(4):422-9. doi: 10.1016/j.evalprogplan.2007.06.004. Epub 2007 Jul 6.
Conflict of interest refers to a set of conditions in which professional judgment concerning the validity of research might be influenced by a secondary competing interest. The competing interest that has received most attention in the literature addressing the prevalence and effects of such conflicts on the practice of empirical research has been that of financial relationships between investigators and research sponsors. The potential for conflicts of interest to arise in the evaluation of drug prevention programs was raised by Moskowitz in this journal in 1993, but to date there has been no attempt made to estimate the scope of this problem. The present study addressed this issue using a sample of "model" school-based drug and violence prevention interventions by first, identifying the types or relationships that exist between program developers and program distributors, and, second, by assessing how many of the evaluations of these programs published in peer-reviewed journals had been conducted by the developers of the programs compared to independent evaluation teams. The data presented indicate that there are relatively few published evaluations that do not involve program developers and that there are few instances in which there is complete separation between the program developer and program distributor. Using the open systems model of the Institute of Medicine Committee on Research Integrity as a framework, it is argued that the culture and norms of the program developer and those of the program evaluator are fundamentally distinct and therefore failure to separate these roles produces high potential for conflict of interest to arise.
利益冲突是指这样一种情况,即有关研究有效性的专业判断可能会受到次要的相互竞争利益的影响。在论述此类冲突在实证研究实践中的普遍性及其影响的文献中,最受关注的相互竞争利益是研究者与研究资助者之间的财务关系。1993年,莫斯科维茨在本期刊中指出了在药物预防项目评估中可能出现利益冲突的问题,但迄今为止,尚未有人尝试估计这一问题的范围。本研究通过选取一批“典型的”以学校为基础的药物和暴力预防干预措施作为样本,来解决这一问题。首先,确定项目开发者与项目推广者之间存在的类型或关系;其次,评估与独立评估团队相比,在同行评审期刊上发表的这些项目评估中有多少是由项目开发者进行的。所呈现的数据表明,相对较少的已发表评估不涉及项目开发者,而且项目开发者与项目推广者完全分离的情况也很少见。以医学研究所研究诚信委员会的开放系统模型为框架,有人认为项目开发者的文化和规范与项目评估者的文化和规范根本不同,因此未能区分这些角色会产生很高的利益冲突可能性。