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自膨式塑料支架治疗食管良性疾病

Self-expanding plastic stents in treatment of benign esophageal conditions.

作者信息

Holm Adrian N, de la Mora Levy Jose G, Gostout Christopher J, Topazian Mark D, Baron Todd H

机构信息

Rochester, Minnesota, USA.

出版信息

Gastrointest Endosc. 2008 Jan;67(1):20-5. doi: 10.1016/j.gie.2007.04.031. Epub 2007 Oct 22.

Abstract

BACKGROUND

Recently, self-expanding plastic stents (SEPSs) have been proposed for the treatment of benign esophageal disease.

OBJECTIVES

Our purpose was to review our experience with SEPSs in patients with benign esophageal conditions.

DESIGN

This was a retrospective case review of patients who underwent SEPS placement for benign esophageal disease, including (1) benign stricture, including reflux disease, ischemia, and idiopathic, (2) radiation-induced strictures, (3) anastomotic strictures, and (4) esophageal leak/fistulae.

PATIENTS

Nineteen male and 11 female patients (average age 52.1 years, range 11-87 years) underwent SEPS placement.

INTERVENTIONS

SEPS placement.

MAIN OUTCOME MEASUREMENTS

Initial complications, stent migration, long-term complications, and treatment success according to clinical symptoms, follow-up endoscopy, or imaging.

RESULTS

Eighty-three of 84 SEPS placements were successful. The most common complications were chest pain, dysphagia, nausea, and vomiting. No deaths were reported from stent placement. Stent migration was more frequent in proximal (30/44 stents, 68.1%) and distal (19/27 stents, 70.4%) compared with mid esophageal (3/10 stents, 30%). Migration was more frequent in stents placed for benign strictures (18/22 stents, 81.8%), anastomotic strictures (18/24 stents, 75%), and fistulae/leak (13/22 stents, 59.1%) compared with radiation-induced strictures (4/14 stents, 28.6%). Only 5 of 83 interventions (6%) resulted in long-term improvement after stent removal.

LIMITATIONS

This was a retrospective review, and patients were selected from a tertiary medical center.

CONCLUSION

Use of SEPSs for benign esophageal conditions resulted in frequent stent migration and few cases of long-term improvement. Further investigation is warranted to identify optimal patient populations and to guide future recommendations for the use of SEPSs.

摘要

背景

最近,有人提出使用自膨胀塑料支架(SEPSs)治疗良性食管疾病。

目的

我们的目的是回顾我们在患有良性食管疾病的患者中使用SEPSs的经验。

设计

这是一项对因良性食管疾病接受SEPS置入术的患者的回顾性病例研究,包括(1)良性狭窄,包括反流性疾病、缺血性和特发性狭窄,(2)放射性狭窄,(3)吻合口狭窄,以及(4)食管漏/瘘。

患者

19例男性和11例女性患者(平均年龄52.1岁,范围11 - 87岁)接受了SEPS置入术。

干预措施

SEPS置入术。

主要观察指标

根据临床症状、随访内镜检查或影像学检查评估初始并发症、支架移位、长期并发症及治疗成功率。

结果

84次SEPS置入术中83次成功。最常见的并发症是胸痛、吞咽困难、恶心和呕吐。未报告因支架置入导致的死亡。与食管中段(3/10个支架,30%)相比,近端(30/44个支架,68.1%)和远端(19/27个支架,70.4%)的支架移位更频繁。与放射性狭窄(4/14个支架,28.6%)相比,用于良性狭窄(18/22个支架,81.8%)、吻合口狭窄(18/24个支架,75%)和瘘/漏(13/22个支架,59.1%)的支架移位更频繁。83次干预中只有5次(6%)在支架取出后实现了长期改善。

局限性

这是一项回顾性研究,且患者选自一家三级医疗中心。

结论

在良性食管疾病中使用SEPSs导致频繁的支架移位,且很少有长期改善的病例。有必要进一步研究以确定最佳患者群体,并为未来SEPSs的使用提供指导建议。

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