Mangieri Regina A, Piomelli Daniele
Department of Pharmacology and Center for Drug Discovery, The University of California, Irvine, CA 92697, USA.
Pharmacol Res. 2007 Nov;56(5):360-6. doi: 10.1016/j.phrs.2007.09.003. Epub 2007 Sep 11.
Cannabinoids are well known modulators of mood and emotional behavior. Current research supports a role for endocannabinoid signaling in the treatment of depression. Changes in levels of the cannabinoid CB(1) receptor or the endogenous CB(1) receptor ligands, anandamide and 2-AG, are observed both in humans suffering from depression and in animal models of depression, and experimental manipulation of CB(1) receptor signaling has also been shown to affect emotional reactivity in rodents. Importantly, inhibitors of anandamide inactivation have demonstrated efficacy in enhancing stress-coping and mood-related behavior. This article will review these areas of research, highlighting the potential of endocannabinoid metabolism modulators as therapeutics for the treatment of depression.
大麻素是众所周知的情绪和情感行为调节剂。目前的研究支持内源性大麻素信号在抑郁症治疗中的作用。在抑郁症患者和抑郁症动物模型中均观察到大麻素CB(1)受体或内源性CB(1)受体配体、花生四烯乙醇胺和2-花生四烯酸甘油水平的变化,并且CB(1)受体信号的实验性操作也已显示会影响啮齿动物的情绪反应性。重要的是,花生四烯乙醇胺失活抑制剂已证明在增强应激应对和情绪相关行为方面具有疗效。本文将综述这些研究领域,强调内源性大麻素代谢调节剂作为抑郁症治疗药物的潜力。