International Clinical Research Centre, Cannabis Facility, St. Anne's University Hospital, Pekařská 53, 602 00 Brno, Czech Republic.
Department of Pharmacology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Biomolecules. 2023 Sep 26;13(10):1446. doi: 10.3390/biom13101446.
The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years. Presently, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). With respect to the psychotropic effects and dependence potential of THC (though it is very mild), its use is associated with certain restrictions, and thus the therapeutic properties of CBD are frequently emphasized because there are no limitations associated with the risk of dependence. Therefore, this review covers the main pharmacodynamic and pharmacokinetic features of CBD (including characteristics of endocannabinoidome) with respect to its possible beneficial effects on selected diseases in clinical practice. A substantial part of the text deals with the main effects of CBD on aging, including Alzheimer's disease and related underlying mechanisms.
近年来，大麻素（大麻植物中特有的物质）在治疗中的应用引起了越来越多的关注。目前，人们主要关注两种大麻素：Δ-9-四氢大麻酚（THC）和大麻二酚（CBD）。鉴于 THC 的精神活性作用和潜在依赖性（尽管非常轻微），其使用受到某些限制，因此经常强调 CBD 的治疗特性，因为不存在与依赖性风险相关的限制。因此，本综述涵盖了 CBD 的主要药效学和药代动力学特征（包括内源性大麻素组的特征），以及其在临床实践中对某些疾病可能产生的有益作用。文本的很大一部分涉及 CBD 对衰老的主要影响，包括阿尔茨海默病和相关的潜在机制。
