用于脑功能慢性微创成像的集成半导体光学传感器。
Integrated semiconductor optical sensors for chronic, minimally-invasive imaging of brain function.
作者信息
Lee Thomas T, Levi Ofer, Cang Jianhua, Kaneko Megumi, Stryker Michael P, Smith Stephen J, Shenoy Krishna V, Harris James S
机构信息
Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
出版信息
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:1025-8. doi: 10.1109/IEMBS.2006.260041.
Intrinsic optical signal (IOS) imaging is a widely accepted technique for imaging brain activity. We propose an integrated device consisting of interleaved arrays of gallium arsenide (GaAs) based semiconductor light sources and detectors operating at telecommunications wavelengths in the near-infrared. Such a device will allow for long-term, minimally invasive monitoring of neural activity in freely behaving subjects, and will enable the use of structured illumination patterns to improve system performance. In this work we describe the proposed system and show that near-infrared IOS imaging at wavelengths compatible with semiconductor devices can produce physiologically significant images in mice, even through skull.
内在光学信号（IOS）成像技术是一种广泛应用于大脑活动成像的技术。我们提出了一种集成设备，该设备由基于砷化镓（GaAs）的半导体光源和探测器交错阵列组成，工作在近红外的电信波长。这种设备将允许对自由活动的受试者进行长期、微创的神经活动监测，并将能够使用结构化照明模式来提高系统性能。在这项工作中，我们描述了所提出的系统，并表明在与半导体器件兼容的波长下进行近红外IOS成像，即使透过颅骨也能在小鼠中产生具有生理意义的图像。
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