Wu Chin-Yeh, Wu Yi-Syuan, Lee Jia-Fu, Huang San-Yuan, Yu Lung, Ko Huei-Chen, Lu Ru-Band
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):447-53. doi: 10.1002/ajmg.b.30626.
Cloninger suggested that type II alcoholism was associated with higher novelty seeking and less harm avoidance behaviors, which was similar to antisocial alcoholism. Most previous studies have failed to recruit subjects that have antisocial personality disorder without alcoholism due to the high coexisting likelihood of having antisocial personality disorder with alcoholism in the majority of the examined populations. Thus, recruitment of individuals with antisocial non-alcoholism (antisocial personality disorder) served as an important control group in examining Cloninger's hypothesis. Due to the documented protective effects against alcoholism of ALDH2*1/*2 or *2/*2 genotype among the Han Chinese population, we recruited antisocial non-alcoholics from the Han Chinese population in Taiwan to verify Cloninger's hypotheses. A total of 127 Han Chinese subjects were recruited who met the diagnosis of antisocial alcoholism (n = 43) or antisocial non-alcoholism (n = 84). We found that the antisocial alcoholism group scored higher on the novelty seeking behavior than did the antisocial non-alcoholism group (t = 2.61, P = 0.01), but no difference was observed on the harm avoidance dimension between these two groups (t = 0.15, P = 0.88). In the novelty seeking scores, after stratification of DRD2 TaqI A genotypes, only a significant difference in 5-HTTLPR polymorphisms between antisocial alcoholics and antisocial non-alcoholics was found, indicating an interaction between DRD2 TaqI A1+ (include A1/A1 or A1/A2) and 5-HTTLPR S/S genotype (t = 2.75, P = 0.01) However, no significant difference was found in the harm avoidance personality trait between these two groups of Han Chinese in Taiwan.
克隆宁格提出，II型酒精中毒与更高的寻求新奇行为和更低的避免伤害行为相关，这与反社会型酒精中毒相似。由于在大多数被研究人群中，反社会型人格障碍与酒精中毒共存的可能性很高，因此之前的大多数研究都未能招募到没有酒精中毒的反社会型人格障碍患者。因此，招募反社会非酒精中毒者（反社会型人格障碍）作为检验克隆宁格假说的重要对照组。由于有文献记载，在汉族人群中，ALDH2*1/2或2/*2基因型对酒精中毒有保护作用，我们从台湾汉族人群中招募了反社会非酒精中毒者来验证克隆宁格的假说。共招募了127名汉族受试者，他们符合反社会型酒精中毒（n = 43）或反社会非酒精中毒（n = 84）的诊断标准。我们发现，反社会型酒精中毒组在寻求新奇行为方面的得分高于反社会非酒精中毒组（t = 2.61，P = 0.01），但在这两组之间的避免伤害维度上未观察到差异（t = 0.15，P = 0.88）。在寻求新奇得分方面，对DRD2 TaqI A基因型进行分层后，仅发现反社会型酒精中毒者与反社会非酒精中毒者在5-HTTLPR多态性上存在显著差异，表明DRD2 TaqI A1+（包括A1/A1或A1/A2）与5-HTTLPR S/S基因型之间存在相互作用（t = 2.75，P = 0.01）。然而，在台湾的这两组汉族人群中，在避免伤害人格特质方面未发现显著差异。
