Kumar Pradeep, Chaudhary Amrita, Rai Vandana
Human Molecular Genetics Laboratory, Department of Biotechnology, VBS Purvanchal University, Jaunpur, UP 222003 India.
Indian J Clin Biochem. 2024 Jul;39(3):301-311. doi: 10.1007/s12291-023-01122-7. Epub 2023 Mar 31.
Several studies are published, that investigated dopamine receptor 2 (DRD2) gene TaqIA polymorphism as a risk factor for alcohol dependence (AD) with positive and negative associations. To derive a more precise estimation of the relationship, a meta-analysis of case-control studies that examined the association between DRD2 gene Taq1A polymorphism and alcohol dependence was performed. Eligible articles were identified through a search of databases including PubMed, Science Direct, Springer link, and Google Scholar. The association between the DRD2 TaqIA polymorphism and AD susceptibility was conducted using odds ratios (ORs) and 95% confidence intervals (95% CIs) as association measures. A total of 69 studies with 9125 cases and 9123 healthy controls were included in the current meta-analysis. Results of the present analysis showed significant association between DRD2 TaqIA polymorphism and AD risk using five genetic modes (allele contrast model-OR 1.22, 95% CI 1.13-1.32, < 0.0001; homozygote model-OR 1.35, 95%CI 1.18-1.55; ≤ 0.0001; dominant model-OR 1.29; 95% CI 1.20-1.39; < 0.0001; recessive model-OR 1.21; 95% CI 1.08-1.36; = 0.0006). There was no significant association found in subgroup analysis, TaqIA polymorphism was not significantly associated with AD risk in the Asian population under all genetic models, but in the Caucasian population, TaqIA polymorphism was significantly associated with AD risk. Overall, results support the hypothesis that DRD2 Taq1A polymorphism plays a role in alcohol dependence.
已有多项研究发表，这些研究调查了多巴胺受体2（DRD2）基因TaqIA多态性作为酒精依赖（AD）风险因素的情况，结果有正相关和负相关。为了更精确地估计这种关系，我们对研究DRD2基因Taq1A多态性与酒精依赖之间关联的病例对照研究进行了荟萃分析。通过搜索包括PubMed、Science Direct、Springer link和Google Scholar在内的数据库来确定符合条件的文章。使用优势比（OR）和95%置信区间（95%CI）作为关联度量来分析DRD2 TaqIA多态性与AD易感性之间的关联。本荟萃分析共纳入了69项研究，其中有9125例病例和9123名健康对照。本分析结果显示，使用五种遗传模式时，DRD2 TaqIA多态性与AD风险之间存在显著关联（等位基因对比模型-OR 1.22，95%CI 1.13 - 1.32，P＜0.0001；纯合子模型-OR 1.35，95%CI 1.18 - 1.55，P≤0.0001；显性模型-OR 1.29，95%CI 1.20 - 1.39，P＜0.0001；隐性模型-OR 1.21，95%CI 1.08 - 1.36，P = 0.0006）。亚组分析未发现显著关联，在所有遗传模型下，TaqIA多态性与亚洲人群的AD风险无显著关联，但在白种人群中，TaqIA多态性与AD风险显著相关。总体而言，结果支持DRD2 Taq1A多态性在酒精依赖中起作用这一假说。
