白细胞介素-8（IL-8 或 CXCL8）-251T/A 和 CXC 趋化因子受体 2（CXCR2）+1208C/T 基因多态性与乳腺癌的关联
Association of interleukin-8 (IL-8 or CXCL8) -251T/A and CXCR2 +1208C/T gene polymorphisms with breast cancer.
作者信息
Kamali-Sarvestani E, Aliparasti M R, Atefi S
机构信息
Department of Immunology, Shiraz Medical School, Shiraz University of Medical School, Shiraz-Iran.
出版信息
Neoplasma. 2007;54(6):484-9.
A case-control study involving 257 breast cancer patients with invasive ductal carcinoma and 233 healthy women was carried out to explore if the IL-8 -251T/A polymorphism and the CXCR2 +1208 C/T polymorphism have a role in breast cancer susceptibility. Genotypic analysis showed an increased frequency of high producer IL-8 -251AA genotype (p=0.016) in the patient group as compared to controls while CXCR2 +1208 C/T polymorphism did not show any differences between studied groups. However, in contrast to IL-8 -251 polymorphism, the percentage of CXCR2 +1208 TT genotype was significantly lower in patients with NPI<or=3.4 compared to NPI>3.4 (2% and 12%, respectively; p=0.03). Also, ER- tumors showed an approximately significant higher CXCR2 +1208 TT genotype compared to ER+ tumors (18.6% and 7.1%, respectively; p=0.07). In conclusion, IL-8 -251T/A polymorphism is associated with development of invasive ductal carcinoma type of breast cancer while CXCR2 +1208C/T polymorphism may affect the disease progression.
开展了一项病例对照研究，纳入257例浸润性导管癌乳腺癌患者和233名健康女性，以探究白细胞介素-8（IL-8）-251T/A多态性和趋化因子受体2（CXCR2）+1208 C/T多态性是否在乳腺癌易感性中起作用。基因型分析显示，与对照组相比，患者组中高表达IL-8 -251AA基因型的频率增加（p = 0.016），而CXCR2 +1208 C/T多态性在研究组之间未显示出任何差异。然而，与IL-8 -251多态性相反，与预后指数（NPI）>3.4的患者相比，NPI≤3.4的患者中CXCR2 +1208 TT基因型的百分比显著降低（分别为2%和12%；p = 0.03）。此外，与雌激素受体（ER）阳性肿瘤相比，ER阴性肿瘤中CXCR2 +1208 TT基因型的比例约显著更高（分别为18.6%和7.1%；p = 0.07）。总之，IL-8 -251T/A多态性与浸润性导管癌型乳腺癌的发生有关，而CXCR2 +1208C/T多态性可能影响疾病进展。
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