Antón Inés M, Jones Gareth E, Wandosell Francisco, Geha Raif, Ramesh Narayanaswamy
Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Trends Cell Biol. 2007 Nov;17(11):555-62. doi: 10.1016/j.tcb.2007.08.005. Epub 2007 Oct 18.
The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP.
细胞的迁移以及一些细胞内病原体（如志贺氏菌和痘苗病毒）的移动依赖于基于肌动蛋白的细胞骨架。许多蛋白质参与调节细胞内基于肌动蛋白的微丝的动态变化，其中，WASP和N-WASP在肌动蛋白聚合的调节中发挥重要作用。在富含肌动蛋白的结构（包括免疫突触、丝状伪足、片状伪足、应力纤维和足体）形成过程中，WASP的活性和稳定性由其细胞伴侣WASP相互作用蛋白（WIP）调节。在此，我们除了综述WIP不依赖于WASP的功能外，还将阐述WIP通过稳定WASP并将其转运至肌动蛋白组装区域来调节WASP功能的作用。
