Creager Andrew J, Madden Christopher R, Bergman Simon, Geisinger Kim R
Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Am J Clin Pathol. 2007 Nov;128(5):740-5. doi: 10.1309/VB1M9D9H7QG6L3R4.
Aneurysmal bone cyst (ABC) is an osseous mass lesion that accounts for 1% of primary bone tumors. We describe 23 cases of ABC initially evaluated by fine-needle aspiration biopsy (FNAB). In 4 cases, the ABC was secondary to another primary tumor. Aspirates from 6 cases (26%) were insufficient. Twelve aspirates diagnosed as ABC by FNAB were confirmed as ABC by histologic examination. The accuracy of FNAB was 82% when cases insufficient for evaluation were excluded. One case diagnosed as ABC cytologically was subsequently found to be metastatic carcinoma. In another, the specimen was interpreted as ABC vs giant cell tumor. In the remainder, a diagnosis of ABC was favored cytologically. Owing to the nonspecific findings, ABC cannot be definitively diagnosed by FNAB. However, the presence of typical clinical and radiographic features in conjunction with a blood-rich, mesenchymal cell containing aspirate devoid of overtly malignant cells strongly suggests the diagnosis of ABC.
动脉瘤样骨囊肿（ABC）是一种骨肿块病变，占原发性骨肿瘤的1%。我们描述了23例最初通过细针穿刺活检（FNAB）评估的ABC病例。其中4例ABC继发于另一种原发性肿瘤。6例（26%）的穿刺样本不足。FNAB诊断为ABC的12例穿刺样本经组织学检查确认为ABC。排除评估不足的病例后，FNAB的准确率为82%。1例细胞学诊断为ABC的病例随后被发现为转移性癌。在另一例中，标本被解释为ABC与巨细胞瘤。其余病例在细胞学上倾向于诊断为ABC。由于结果不具特异性，FNAB不能确诊ABC。然而，典型的临床和影像学特征，加上富含血液、含有间充质细胞且无明显恶性细胞的穿刺样本，强烈提示ABC的诊断。
