de Haas A H, van Weering H R J, de Jong E K, Boddeke H W G M, Biber K P H
Department of Medical Physiology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Mol Neurobiol. 2007 Oct;36(2):137-51. doi: 10.1007/s12035-007-0036-8. Epub 2007 Jul 10.
Whereas chemokines are well known for their ability to induce cell migration, only recently it became evident that chemokines also control a variety of other cell functions and are versatile messengers in the interaction between a diversity of cell types. In the central nervous system (CNS), chemokines are generally found under both physiological and pathological conditions. Whereas many reports describe chemokine expression in astrocytes and microglia and their role in the migration of leukocytes into the CNS, only few studies describe chemokine expression in neurons. Nevertheless, the expression of neuronal chemokines and the corresponding chemokine receptors in CNS cells under physiological and pathological conditions indicates that neuronal chemokines contribute to CNS cell interaction. In this study, we review recent studies describing neuronal chemokine expression and discuss potential roles of neuronal chemokines in neuron-astrocyte, neuron-microglia, and neuron-neuron interaction.
趋化因子以其诱导细胞迁移的能力而闻名，直到最近才发现趋化因子还能控制多种其他细胞功能，并且在多种细胞类型之间的相互作用中是多功能信使。在中枢神经系统（CNS）中，通常在生理和病理条件下都能发现趋化因子。虽然许多报告描述了趋化因子在星形胶质细胞和小胶质细胞中的表达及其在白细胞向中枢神经系统迁移中的作用，但只有少数研究描述了趋化因子在神经元中的表达。然而，在生理和病理条件下，中枢神经系统细胞中神经元趋化因子及其相应趋化因子受体的表达表明，神经元趋化因子有助于中枢神经系统细胞间的相互作用。在本研究中，我们回顾了描述神经元趋化因子表达的近期研究，并讨论了神经元趋化因子在神经元-星形胶质细胞、神经元-小胶质细胞和神经元-神经元相互作用中的潜在作用。
