Zhu Shenmin, Zhou Zhengyang, Zhang Di
State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
Chemphyschem. 2007 Dec 3;8(17):2478-83. doi: 10.1002/cphc.200700362.
A site-selective controlled delivery system for controlled drug release is fabricated through the in situ assembly of stimuli-responsive ordered SBA-15 and magnetic particles. This approach is based on the formation of ordered mesoporous silica with magnetic particles formed from Fe(CO)5 via the surfactant-template sol-gel method and control of transport through polymerization of N-isopropyl acrylamide inside the pores. Hydrophobic Fe(CO)5 acts as a swelling agent as well as being the source of the magnetic particles. The obtained system demonstrates a high pore diameter (7.1 nm) and pore volume (0.41 cm(3) g(-1)), which improves drug storage for relatively large molecules. Controlled drug release through the porous network is demonstrated by measuring the uptake and release of ibuprofen (IBU). The delivery system displays a high IBU storage capacity of 71.5 wt %, which is almost twice as large as the highest value based on SBA-15 ever reported. In vitro testing of IBU loading and release exhibits a pronounced transition at around 32 degrees C, indicating a typical thermosensitive controlled release.
通过刺激响应性有序SBA-15和磁性颗粒的原位组装制备了一种用于药物控释的位点选择性控释系统。该方法基于通过表面活性剂模板溶胶-凝胶法由Fe(CO)5形成的磁性颗粒形成有序介孔二氧化硅，并通过孔内N-异丙基丙烯酰胺的聚合来控制传输。疏水性Fe(CO)5既作为溶胀剂又作为磁性颗粒的来源。所获得的系统显示出高孔径（7.1nm）和孔体积（0.41cm³ g⁻¹），这提高了对相对大分子的药物储存能力。通过测量布洛芬（IBU）的摄取和释放证明了通过多孔网络的药物控释。该递送系统显示出71.5 wt%的高IBU储存容量，几乎是基于SBA-15报道的最高值的两倍。IBU负载和释放的体外测试在约32℃处表现出明显的转变，表明典型的热敏控释。
