诺维科夫肝癌中的地塞米松受体。糖皮质激素治疗期间其特性、浓度及核摄取的变化
The dexamethasone receptor in the Novikoff Hepatoma. Characterization and changes in concentration and nuclear uptake during glucocorticoid therapy.
作者信息
Liu S L, McNamara D J, Webb T E
出版信息
Biochem J. 1975 Dec;152(3):689-95. doi: 10.1042/bj1520689.
Abstract
Novikoff hepatoma ascites cells, grown intraperitoneally in rats, are shown to possess a high-affinity, low-capacity dexamethasone-binding protein. The receptor protein has an intracellular localization and concentration, association constant (Ka), glucocorticoid specificity and nuclear uptake in the presence of dexamethasone comparable with those of the G-protein of rat liver. During therapy of the tumour-bearing animal with cortisol, marked cyclic variations were observed in the concentration and nuclear uptake of the putative G-protein in the tumor cells; more transient variations were also observed in the Ka value of the receptor protein.
摘要
在大鼠腹腔内生长的诺维科夫肝癌腹水细胞被证明具有一种高亲和力、低容量的地塞米松结合蛋白。该受体蛋白具有细胞内定位和浓度、缔合常数（Ka）、糖皮质激素特异性以及在存在地塞米松的情况下与大鼠肝脏的G蛋白相当的核摄取。在用皮质醇治疗荷瘤动物期间，观察到肿瘤细胞中假定的G蛋白的浓度和核摄取有明显的周期性变化；受体蛋白的Ka值也观察到更短暂的变化。
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引用本文的文献
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