Overgaard Marie, Kvistgaard Marianne Ewertz, Thomsen Mette Skovhus
Arhus Universitetshospital, Arhus Sygehus.
Ugeskr Laeger. 2007 Sep 3;169(36):2993-6.
Postoperative radiotherapy (RT) is an important part of the multidisciplinary treatment of early breast cancer. Meta-analyses of large randomized trials of RT after lumpectomy and mastectomy have shown that RT reduces the risk of local recurrence with at least 70% and mortality after 15 years with 5%. The effect is most pronounced in patients with a high risk of local recurrence, but is independent of adjuvant systemic treatment. Late radiation effects, in particular cardiac mortality can now be avoided using modern treatment technique. However, there is a continuous need to find the overall balance between the risk and benefit of RT based on individual prognostic parameters and technical possibilities.
术后放疗是早期乳腺癌多学科治疗的重要组成部分。对保乳手术和乳房切除术后放疗的大型随机试验进行的荟萃分析表明,放疗可将局部复发风险降低至少70%,并将15年后的死亡率降低5%。这种效果在局部复发高风险患者中最为显著,但与辅助性全身治疗无关。使用现代治疗技术现在可以避免晚期放射效应,特别是心脏死亡率。然而,基于个体预后参数和技术可能性,持续需要找到放疗风险与获益之间的总体平衡。