Knoop Ann Søegaard, Rasmussen Birgitte Bruun
Odense Universitetshospital, Onkologisk Afdeling R, Odense C.
Ugeskr Laeger. 2007 Sep 3;169(36):2997-9.
There is a long tradition for defining prognostic factors in breast carcinoma; the classic ones being lymphnode status, tumor size, malignancy grade, and hormone receptor status. More important are the detection of predictive factors, defined as factors in the tumor which predict the effect of a certain treatment. The hormone receptors are a classic example of predictive factors for determining whether patients should be offered endocrine treatment. New predictive factors are HER2 for predicting the effect of trastuzumab and TOP2A for predicting the effect of certain chemotherapies.
在乳腺癌中定义预后因素有着悠久的传统；经典的预后因素包括淋巴结状态、肿瘤大小、恶性程度分级和激素受体状态。更重要的是预测因素的检测，预测因素被定义为肿瘤中能够预测某种治疗效果的因素。激素受体是决定患者是否应接受内分泌治疗的预测因素的经典例子。新的预测因素有用于预测曲妥珠单抗疗效的HER2以及用于预测某些化疗疗效的TOP2A。
