Uguz Faruk, Gezginc Kazim, Zeytinci Ismet Esra, Karatayli Savas, Askin Rustem, Guler Ozkan, Sahin Figen Kir, Emul H Murat, Ozbulut Omer, Gecici Omer
Department of Psychiatry, Meram Faculty of Medicine, Selçuk University, 42080 Konya, Turkey.
Compr Psychiatry. 2007 Nov-Dec;48(6):558-61. doi: 10.1016/j.comppsych.2007.05.010. Epub 2007 Aug 20.
The aim of the current study was to prospectively examine a course of obsessive-compulsive disorder (OCD) during the early postpartum period.
The study data were collected from 16 pregnant women with a diagnosis of OCD according to the Structured Clinical Interview for DSM-IV (SCID-I). Obsessive-compulsive disorder symptoms were assessed by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) before and after childbirth. Psychopharmacologic or psychotherapeutic treatments were not administered over the study period.
Scores of the mean Y-BOCS-total and Y-BOCS-obsession were significantly reduced from the basal levels to 6 weeks postnatally. No significant difference was found in terms of Y-BOCS-compulsion between 2 interviews. During the study period, whereas the Y-BOCS-total scores were decreased by at least 25% in 8 (50.0%) of 16 patients, only 1 (6.2%) of 16 patients experienced at least a 25% increase in the same scores.
The results from a small patient group suggest that some patients may experience a marked improvement in preexisting OCD symptoms after childbirth.
本研究的目的是前瞻性地考察产后早期强迫症（OCD）的病程。
研究数据来自16名根据《精神疾病诊断与统计手册》第四版结构化临床访谈（SCID-I）被诊断为强迫症的孕妇。在分娩前后，通过耶鲁-布朗强迫症量表（Y-BOCS）评估强迫症症状。在研究期间未给予心理药物或心理治疗。
Y-BOCS总分和Y-BOCS强迫观念得分从基线水平到产后6周显著降低。两次访谈之间在Y-BOCS强迫行为方面未发现显著差异。在研究期间，16名患者中有8名（50.0%）的Y-BOCS总分至少降低了25%，而16名患者中只有1名（6.2%）的相同得分至少增加了25%。
来自一个小患者群体的结果表明，一些患者在产后可能会出现原有强迫症症状的显著改善。
