Figueiredo A, Moreira P, Parada B, Nunes P, Macário F, Bastos C, Mota A
Department of Urology and Renal Transplantation, Hospitais da Universidade de Coimbra, 3049 Coïmbra Codex, Portugal.
Transplant Proc. 2007 Oct;39(8):2473-5. doi: 10.1016/j.transproceed.2007.07.032.
The objective of this study was to evaluate the risk factors for delayed graft function (DGF) and their influence on renal graft outcome.
We reviewed 1462 consecutive renal transplantation and identified 245 patients (17.1%) with delayed graft function and 1120 patients with immediate graft function. Forty-one cases were excluded because of a nonfunctioning graft as well as 26 other cases because of insufficient data. We compared the incidence, donor and recipient risk factors, and impact on graft outcomes, as well as patient and graft survival of delayed graft function.
Donor weight and age, recipient weight, age, length of dialysis, and cold ischemia time were significantly higher in the delayed graft function group. Higher rates of acute rejection and chronic graft dysfunction were observed in this group of patients; we also observed worse graft function and survival.
Multiple risk factors are associated with delayed graft function, which contribute decisively to a worse outcome.
本研究的目的是评估移植肾功能延迟（DGF）的危险因素及其对肾移植结果的影响。
我们回顾了1462例连续的肾移植病例，确定了245例（17.1%）移植肾功能延迟的患者和1120例移植肾功能立即恢复的患者。41例因移植肾无功能被排除，另有26例因数据不足被排除。我们比较了移植肾功能延迟的发生率、供体和受体危险因素、对移植结果的影响以及患者和移植肾的存活率。
移植肾功能延迟组的供体体重和年龄、受体体重、年龄、透析时间和冷缺血时间显著更高。该组患者急性排斥反应和慢性移植肾功能障碍的发生率更高；我们还观察到移植肾功能和存活率更差。
多种危险因素与移植肾功能延迟相关，这对更差的结果起决定性作用。
