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原位双腔心脏移植中预防性供体三尖瓣环成形术

Prophylactic donor tricuspid annuloplasty in orthotopic bicaval heart transplantation.

作者信息

Fiorelli A I, Stolf N A G, Abreu Filho C A C, Santos R H B, Buco F H A, Fiorelli L R, Issa V, Bacal F, Bocchi E A

机构信息

Heart Institute of Medicine School of São Paulo University, Rua Morgado de Mateus 126/81, CEP 04015-050, São Paulo/SP, Brazil.

出版信息

Transplant Proc. 2007 Oct;39(8):2527-30. doi: 10.1016/j.transproceed.2007.07.025.

Abstract

OBJECTIVE

The objective of this study was to evaluate the effects of prophylactic heart donor tricuspid annuloplasty to improve the degree of valvar regurgitation and the hemodynamic performance after orthotopic heart transplantation using bicaval anastomosis.

METHODS

From March 1985 to December 2005, of the 368 patients undergoing orthotopic heart transplantation, 20 patients were selected because they survived more than 6 months. They were divided into 2 groups: group I-10 patients underwent prophylactic heart donor tricuspid annuloplasty by the De Vega technique; group II-10 patients did not receive a graft with this procedure. Their presurgical clinical characteristics were the same. In the postsurgical period, tricuspid regurgitation degree evaluated by transthoracic Doppler echocardiography was qualified from 0 to 3: 0 = absent; 1 = mild; 2 = moderate; and 3 = severe. Myocardial performance was evaluated by the ventricular ejection fraction and by an invasive hemodynamic study, performed during routine endomyocardial biopsies.

RESULTS

At a follow-up of 14.6 +/- 4.3 months (6 and 16 months), group I showed no mortality, whereas group II had 10% (P > .05). However, it was not related to the annuloplasty. The mean degree of tricuspid regurgitation in group I was 0.4 +/- 0.6; in group II, 1.6 +/- 0.8 (P < .05). There was a significant difference between the 2 groups in the right atrium pressure, which was higher in group II.

CONCLUSIONS

Prophylactic tricuspid annuloplasty in the heart donor significantly reduced the degree of valvular regurgitation after heart transplantation using a bicaval anastomosis without significantly interfering with the hemodynamic performance of the allograft.

摘要

目的

本研究的目的是评估预防性心脏供体三尖瓣环成形术对采用双腔静脉吻合术的原位心脏移植术后瓣膜反流程度及血流动力学表现的影响。

方法

1985年3月至2005年12月,在368例行原位心脏移植的患者中,选取存活超过6个月的20例患者。将其分为2组:I组-10例患者采用De Vega技术行预防性心脏供体三尖瓣环成形术;II组-10例患者未接受该手术。两组患者术前临床特征相同。术后,经胸多普勒超声心动图评估三尖瓣反流程度,分为0至3级:0级=无反流;1级=轻度;2级=中度;3级=重度。通过心室射血分数及在常规心内膜心肌活检时进行的有创血流动力学研究评估心肌功能。

结果

在14.6±4.3个月(6至16个月)的随访中,I组无死亡病例,而II组死亡率为10%(P>.05)。然而,这与环成形术无关。I组三尖瓣反流平均程度为0.4±0.6;II组为1.6±0.8(P<.05)两组右心房压力存在显著差异,II组更高。

结论

心脏供体预防性三尖瓣环成形术可显著降低采用双腔静脉吻合术的心脏移植术后瓣膜反流程度,且对同种异体移植物的血流动力学表现无显著干扰。

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