伴有新型染色体畸变der(5)t(4;5)(q31;q31.3)和t(14;17)(q32;q23)的儿童髓系/自然杀伤前体急性白血病
Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23).
作者信息
Abdelhaleem Mohamed, Shago Mary, Sayeh Ebrahim, Abla Oussama
机构信息
Division of Haematopathology, Department of Paediatric Laboratory Medicine, Room 3691, Atrium, Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
Cancer Genet Cytogenet. 2007 Oct 15;178(2):141-3. doi: 10.1016/j.cancergencyto.2007.05.027.
We report a unique case of childhood acute leukemia. The leukemia blasts had lymphoblastoid appearance and expressed CD33, CD13, CD34, CD4, CD7, and CD56. The morphology and immunophenotype were most consistent with myeloid/natural killer precursor acute leukemia. The blasts had a complex karyotype, including two chromosomal aberrations, der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23), not previously described in childhood acute leukemia. The patient achieved morphological remission following myeloid-based leukemia therapy.
我们报告了一例独特的儿童急性白血病病例。白血病原始细胞具有淋巴母细胞样外观，并表达CD33、CD13、CD34、CD4、CD7和CD56。其形态学和免疫表型与髓系/自然杀伤前体急性白血病最为相符。原始细胞具有复杂的核型，包括两种染色体畸变，即der(5)t(4;5)(q31;q31.3)和t(14;17)(q32;q23)，这在儿童急性白血病中此前未曾描述过。该患者在接受基于髓系的白血病治疗后实现了形态学缓解。
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